The effects of chloroquine on bleeding time and disappearance of platelet 5-hydroxytryptamine in rabbits.
Identifieur interne : 003896 ( Main/Exploration ); précédent : 003895; suivant : 003897The effects of chloroquine on bleeding time and disappearance of platelet 5-hydroxytryptamine in rabbits.
Auteurs : RBID : pubmed:11150411English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Carbon Radioisotopes, Indium Radioisotopes, Serotonin.
- chemical , pharmacology : Antirheumatic Agents, Chloroquine.
- drug effects : Blood Platelets.
- metabolism : Blood Platelets.
- Animals, Bleeding Time, Rabbits.
Abstract
Chloroquine inhibits platelet aggregation in vitro and in vivo. Because inhibition of platelet aggregation may prolong bleeding time, the effect of chloroquine administration on bleeding time and disappearance of platelet serotonin, which may affect bleeding time, were studied.
PubMed: 11150411
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of chloroquine on bleeding time and disappearance of platelet 5-hydroxytryptamine in rabbits.</title><author><name sortKey="Osim, E" uniqKey="Osim E">E Osim</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Physiology, Anatomy, Haematology, and Pharmacy, Faculty of Medicine, University of Zimbabwe, Harare, Zimbabwe.</nlm:affiliation><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Departments of Physiology, Anatomy, Haematology, and Pharmacy, Faculty of Medicine, University of Zimbabwe, Harare</wicri:regionArea></affiliation></author><author><name sortKey="Mbajiorgu, F" uniqKey="Mbajiorgu F">F Mbajiorgu</name></author><author><name sortKey="Nkomo, I" uniqKey="Nkomo I">I Nkomo</name></author><author><name sortKey="Coutts, A" uniqKey="Coutts A">A Coutts</name></author><author><name sortKey="Munjeri, O" uniqKey="Munjeri O">O Munjeri</name></author><author><name sortKey="Vaz, R" uniqKey="Vaz R">R Vaz</name></author><author><name sortKey="Arthur, S" uniqKey="Arthur S">S Arthur</name></author><author><name sortKey="Musabayane, C" uniqKey="Musabayane C">C Musabayane</name></author></titleStmt><publicationStmt><date when="2000">2000</date><idno type="RBID">pubmed:11150411</idno><idno type="pmid">11150411</idno><idno type="wicri:Area/Main/Corpus">003B23</idno><idno type="wicri:Area/Main/Curation">003B23</idno><idno type="wicri:Area/Main/Exploration">003896</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antirheumatic Agents (pharmacology)</term><term>Bleeding Time</term><term>Blood Platelets (drug effects)</term><term>Blood Platelets (metabolism)</term><term>Carbon Radioisotopes (metabolism)</term><term>Chloroquine (pharmacology)</term><term>Indium Radioisotopes (metabolism)</term><term>Rabbits</term><term>Serotonin (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carbon Radioisotopes</term><term>Indium Radioisotopes</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antirheumatic Agents</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bleeding Time</term><term>Rabbits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine inhibits platelet aggregation in vitro and in vivo. Because inhibition of platelet aggregation may prolong bleeding time, the effect of chloroquine administration on bleeding time and disappearance of platelet serotonin, which may affect bleeding time, were studied.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11150411</PMID><DateCreated><Year>2001</Year><Month>02</Month><Day>12</Day></DateCreated><DateCompleted><Year>2001</Year><Month>02</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1074-2484</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>3</Issue><PubDate><Year>2000</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of cardiovascular pharmacology and therapeutics</Title><ISOAbbreviation>J. Cardiovasc. Pharmacol. Ther.</ISOAbbreviation></Journal><ArticleTitle>The effects of chloroquine on bleeding time and disappearance of platelet 5-hydroxytryptamine in rabbits.</ArticleTitle><Pagination><MedlinePgn>223-8</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Chloroquine inhibits platelet aggregation in vitro and in vivo. Because inhibition of platelet aggregation may prolong bleeding time, the effect of chloroquine administration on bleeding time and disappearance of platelet serotonin, which may affect bleeding time, were studied.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Platelets were harvested from 12 rabbits. They were labelled with (111)In to tag individual platelets and (14)C-labelled 5-hydroxytryptamine (5HT) or serotonin. Doubly labelled platelets from the rabbits were returned to their donors. At timed intervals, from 2 to 66 hours, blood samples were drawn and platelets collected. (111)In and (14)C were separately counted. In 6 experiments, the animals served as control and received normal saline intraperitoneally (IP) daily for 4 days; the other 6 rabbits served as test and were given a therapeutic dose of chloroquine phosphate (10 mg/kg, IP) daily for 4 days. Indium disappeared in an exponential fashion in both control and test groups. The fraction of indium disappearing per hour was significantly less in chloroquine-treated rabbits than in control rabbits (P <.001). Ninety-nine percent of the indium-labelled platelets disappeared in 7.0 days in chloroquine-treated rabbits and 5.8 days in control rabbits (P <.001). Bleeding times in chloroquine-treated and control rabbits were not significantly different (64.8 +/- 2.2 vs. 62.3 +/- 4.0 sec, respectively). However, the labelled platelet serotonin disappeared more slowly in chloroquine-treated rabbits than in control rabbits. (K for chloroquine-treated and control rabbits was 0.0096 +/- 0.0064 and 0. 0254 +/- 0.0016; respectively, P <.001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Chloroquine prolongs platelet survival but does not affect bleeding time in rabbits. Chloroquine also slows down the disappearance of labelled platelet serotonin. We propose that chloroquine increases the recycling of platelet 5HT, passing it on from platelet to platelet in rabbits and this may have a role in the maintenance of hemostasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Osim</LastName><ForeName>E</ForeName><Initials>E</Initials><Affiliation>Departments of Physiology, Anatomy, Haematology, and Pharmacy, Faculty of Medicine, University of Zimbabwe, Harare, Zimbabwe.</Affiliation></Author><Author ValidYN="Y"><LastName>Mbajiorgu</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Nkomo</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Coutts</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Munjeri</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Vaz</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Arthur</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Musabayane</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>J Cardiovasc Pharmacol Ther</MedlineTA><NlmUniqueID>9602617</NlmUniqueID><ISSNLinking>1074-2484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>333DO1RDJY</RegistryNumber><NameOfSubstance>Serotonin</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance>Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Bleeding Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carbon Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Serotonin</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>1</Month><Day>11</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>3</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>1</Month><Day>11</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11150411</ArticleId><ArticleId IdType="pii">ajcpt0050223</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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